Fosfomycin Sodium Powder

Fosfomycin Sodium Powder - Pharmaceutical Grade Antibiotic API

Xi'an Linnas Biotech Co., Ltd. manufactures pharmaceutical-grade Fosfomycin Sodium Powder has a 99% purity specification, fulfilling strict quality requirements for the manufacturing of antibiotic APIs. This broad-spectrum phosphonic acid derivative uses a special mechanism of MurA enzyme inhibition to target bacterial infections that are resistant to many drugs. With thorough testing procedures, our ISO 9001-certified production facility guaranties consistent batch quality. Our product, which comes in 20 kg, 25 kg, and 50 kg drum packing, has a pH range of 9.0–10.5 in 5% solution while maintaining the look of white crystalline powder. Fast delivery within 3 days after payment confirmation supports your production scheduling requirements. Samples are available for quality evaluation before bulk orders.

What Is Fosfomycin Sodium Powder

Phosphonic acid is the source of our powder, which is a sterile, broad-spectrum antimicrobial Active Pharmaceutical Ingredient. It functions in a unique way by blocking UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA enzyme), in contrast to beta-lactam or aminoglycoside antibiotics. This prevents bacteria from synthesizing their cell walls.

Intravenous or intramuscular injection is made possible by the sodium salt formulation. Its low molecular weight makes it easier to penetrate tissues, such as biofilm environments, bone, and cerebrospinal fluid. A phosphonic acid structure that prevents cross-resistance with other antimicrobial classes is represented by the chemical formula C3H5Na2O4P.

Because of this, it is useful for salvage therapy in patients who are very sick. The substance has very little protein binding (around 0%), which guaranties a high concentration of free drug in tissues and serum.

Technical Specifications

Clinical Applications

Critical Care & Sepsis Management

Your hospital-grade formulations require reliable API for treating severe sepsis and septic shock caused by Gram-negative bacteria. The Fosfomycin Sodium Powder performs effectively in combination with carbapenems or piperacillin-tazobactam. This synergistic approach prevents resistance emergence during prolonged therapy in ICU environments.

Bone and Orthopedic Infections

This API is perfect for treating osteomyelitis because of its exceptional osseous tissue penetration. Even in the hypoxic and necrotic tissue conditions common to deep bone abscesses, it retains its antibacterial efficacy. Its resilience in difficult physiological conditions is advantageous for your orthopedic injectable compositions.

Complex Infections of the Urinary Tract

The API promotes quick bacterial clearance in catheter-associated UTIs and pyelonephritis involving MDR pathogens. Renal excretion that is not metabolized guaranties a high concentration at the sites of infection. This avoids the systemic dilution problems that other antibiotics frequently cause.

Core Advantages Against Multi-Drug Resistance

Fighting Superbugs

MRSA (Methicillin-resistant Staphylococcus aureus), VRE (Vancomycin-resistant Enterococci), and ESBL-producing Enterobacteriaceae are all successfully targeted by the product. This API gives your pharmaceutical formulations alternate treatment options in the event that conventional first-line antibiotics do not work.

Capability of Biofilm Penetration

Because of its low molecular weight, it can pass thru biofilms in cases of prosthetic joint infections or cystic fibrosis. This tackles persistent recurrence problems that pose a barrier to traditional antibiotic treatments. Your products have the ability to target bacterial colonies that are resistant to other treatments.

Absence of a Cross-Resistance Pattern

There is no cross-resistance between the distinct phosphonic acid structure and aminoglycosides, beta-lactams, or fluoroquinolones. For critically ill patients, this makes it a crucial part of combination therapy. When creating multi-drug regimens, your formulation development becomes more flexible.

Quality Control & Manufacturing Standards

Every step of the manufacturing process is subject to stringent quality control in our production facility. Batch-to-batch uniformity is guarantyd by sophisticated analytical tools and automated production lines. Pharmacopeia criteria are followed while choosing raw materials, and supplier certifications are verified.

Important factors like pH, optical rotation, and impurity levels are tracked by in-process quality checks. Microbiological testing for sterility assurance and HPLC analysis for purity verification are two aspects of final product testing. A Certificate of Analysis attesting to compliance with specifications is given to each batch.

To guarantee the stability of the hygroscopic powder, we keep storage conditions under strict control. Product integrity is safeguarded throughout transit by packaging in moisture-resistant drums with nitrogen flushing. Consistent product performance throughout shipments can be confirmed by your receiving quality control.

Frequently Asked Questions

Q: What legal requirements is your Fosfomycin Sodium Powder compliant with?

A: Our product adheres to pharmacopeia recommendations for purity, optical rotation, and impurity control as well as ISO 9001 quality management requirements. For regulatory submissions, we offer complete paperwork, including a Certificate of Analysis.

Q: What is the average lead time for large orders?

A: For stock amounts, standard shipping occurs three days after payment confirmation. Depending on volume, larger custom orders might take 7–14 days. For special timeline requirements, we advise getting in touch with us.

Q: Is it possible for you to offer samples for the creation of formulations?

A: We do provide samples for compatibility testing and quality assessment. This enables your R&D team to confirm performance prior to making large expenditures. Our technical staff may arrange for sample requests.

Q: What qualifies your API for use in veterinary applications?

A: It can be used for poultry treatments, aquatic products, and animal health due to its broad-spectrum activity and 99% purity standard. However, you should confirm that your target markets are compliant with certain veterinary drug standards.

Q: What is the best way to store the product?

A: Keep in tightly sealed containers out of direct sunlight and in a cool, dry location. Reduce its exposure to air and moisture because it is hygroscopic. During the product's 24-month shelf life, proper storage preserves its stability.

Contact Us

Ready to use the Fosfomycin Sodium Powder to secure reliable pharmaceutical-grade API for your formulations? Contact our technical team at cathy@linnas.com.cn for quotations, technical data sheets, and sample requests.